31P magnetic resonance spectroscopy in alzheimer's and pick's disease

C. D. Smith; L. G. Gallenstein; W. J. Layton; R. J. Kryscio; W. R. Markesbery

doi:10.1016/0197-4580(93)90026-8

³¹P magnetic resonance spectroscopy in alzheimer's and pick's disease

C. D. Smith
, L. G. Gallenstein
, W. J. Layton
, R. J. Kryscio
, W. R. Markesbery

Producción científica: Article › revisión exhaustiva

38 Citas (Scopus)

Resumen

-Previous studies have suggested a defect in phosphorus metabolism in Alzheimer's disease (AD) gray matter. We have studied phosphorus metabolites in both gray and white matter in autopsy specimens of nine subjects with late-stage AD, three with Pick's disease and seven age-matched controls. Phosphorus metabolites sugar phosphate (SU), phosphomonoester (PME). phosphodiester (PD), and inorganic phosphate (PI) were quantified as mole percentages in regional neocortical specimens using nuclear magnetic resonance spectroscopy. Senile plaque (SP) and neurofibrillary tangle (NFT) counts were determined in adjacent cortical sections. In the inferior parietal lobule gray and white matter, mole percentage normalized PME, and PD were significantly greater than control values in both AD and Pick's disease. A significant correlation was found between PD and NFT in AD parietal gray matter. Our data indicates that phosphorus metabolite alterations are present in two cortical degenerative diseases and are not likely to be specific for AD.

Idioma original	English
Páginas (desde-hasta)	85-92
Número de páginas	8
Publicación	Neurobiology of Aging
Volumen	14
N.º	1
DOI	https://doi.org/10.1016/0197-4580(93)90026-8
Estado	Published - 1993

Nota bibliográfica

Funding Information:
Supported in part by NIH grants IP50-AG50144 and 1POI-AG05119. Dr. Smith is supported by a Clinical Investigator Development Award, NINDS, #IKO8NS 01421-01. We thank John Hunsaker and Larry Sparks for obtaining control specimens and Audrey Neilsen and Paula Thomason for helping prepare the manuscript.

Financiación

Supported in part by NIH grants IP50-AG50144 and 1POI-AG05119. Dr. Smith is supported by a Clinical Investigator Development Award, NINDS, #IKO8NS 01421-01. We thank John Hunsaker and Larry Sparks for obtaining control specimens and Audrey Neilsen and Paula Thomason for helping prepare the manuscript.

Financiadores	Número del financiador
National Institutes of Health (NIH)	IP50-AG50144
National Institute on Aging	P01AG005119
National Institute of Neurological Disorders and Stroke	8NS 01421-01

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Acceder al documento

10.1016/0197-4580(93)90026-8

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title = "31P magnetic resonance spectroscopy in alzheimer's and pick's disease",

abstract = "-Previous studies have suggested a defect in phosphorus metabolism in Alzheimer's disease (AD) gray matter. We have studied phosphorus metabolites in both gray and white matter in autopsy specimens of nine subjects with late-stage AD, three with Pick's disease and seven age-matched controls. Phosphorus metabolites sugar phosphate (SU), phosphomonoester (PME). phosphodiester (PD), and inorganic phosphate (PI) were quantified as mole percentages in regional neocortical specimens using nuclear magnetic resonance spectroscopy. Senile plaque (SP) and neurofibrillary tangle (NFT) counts were determined in adjacent cortical sections. In the inferior parietal lobule gray and white matter, mole percentage normalized PME, and PD were significantly greater than control values in both AD and Pick's disease. A significant correlation was found between PD and NFT in AD parietal gray matter. Our data indicates that phosphorus metabolite alterations are present in two cortical degenerative diseases and are not likely to be specific for AD.",

keywords = "Alzheimer's disease, Phosphodiesters, Phosphomonoester, Phosphorus magnetic resonance spectroscopy, Pick's disease",

author = "Smith, \{C. D.\} and Gallenstein, \{L. G.\} and Layton, \{W. J.\} and Kryscio, \{R. J.\} and Markesbery, \{W. R.\}",

note = "Funding Information: Supported in part by NIH grants IP50-AG50144 and 1POI-AG05119. Dr. Smith is supported by a Clinical Investigator Development Award, NINDS, \#IKO8NS 01421-01. We thank John Hunsaker and Larry Sparks for obtaining control specimens and Audrey Neilsen and Paula Thomason for helping prepare the manuscript.",

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AU - Smith, C. D.

AU - Gallenstein, L. G.

AU - Layton, W. J.

AU - Kryscio, R. J.

AU - Markesbery, W. R.

N1 - Funding Information: Supported in part by NIH grants IP50-AG50144 and 1POI-AG05119. Dr. Smith is supported by a Clinical Investigator Development Award, NINDS, #IKO8NS 01421-01. We thank John Hunsaker and Larry Sparks for obtaining control specimens and Audrey Neilsen and Paula Thomason for helping prepare the manuscript.

PY - 1993

Y1 - 1993

N2 - -Previous studies have suggested a defect in phosphorus metabolism in Alzheimer's disease (AD) gray matter. We have studied phosphorus metabolites in both gray and white matter in autopsy specimens of nine subjects with late-stage AD, three with Pick's disease and seven age-matched controls. Phosphorus metabolites sugar phosphate (SU), phosphomonoester (PME). phosphodiester (PD), and inorganic phosphate (PI) were quantified as mole percentages in regional neocortical specimens using nuclear magnetic resonance spectroscopy. Senile plaque (SP) and neurofibrillary tangle (NFT) counts were determined in adjacent cortical sections. In the inferior parietal lobule gray and white matter, mole percentage normalized PME, and PD were significantly greater than control values in both AD and Pick's disease. A significant correlation was found between PD and NFT in AD parietal gray matter. Our data indicates that phosphorus metabolite alterations are present in two cortical degenerative diseases and are not likely to be specific for AD.

AB - -Previous studies have suggested a defect in phosphorus metabolism in Alzheimer's disease (AD) gray matter. We have studied phosphorus metabolites in both gray and white matter in autopsy specimens of nine subjects with late-stage AD, three with Pick's disease and seven age-matched controls. Phosphorus metabolites sugar phosphate (SU), phosphomonoester (PME). phosphodiester (PD), and inorganic phosphate (PI) were quantified as mole percentages in regional neocortical specimens using nuclear magnetic resonance spectroscopy. Senile plaque (SP) and neurofibrillary tangle (NFT) counts were determined in adjacent cortical sections. In the inferior parietal lobule gray and white matter, mole percentage normalized PME, and PD were significantly greater than control values in both AD and Pick's disease. A significant correlation was found between PD and NFT in AD parietal gray matter. Our data indicates that phosphorus metabolite alterations are present in two cortical degenerative diseases and are not likely to be specific for AD.

KW - Alzheimer's disease

KW - Phosphodiesters

KW - Phosphomonoester

KW - Phosphorus magnetic resonance spectroscopy

KW - Pick's disease

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