Survival trial design and monitoring using historical controls

Jianrong Wu; Xiaoping Xiong

doi:10.1002/pst.1756

Survival trial design and monitoring using historical controls

Jianrong Wu
, Xiaoping Xiong

Internal Medicine

Producción científica: Article › revisión exhaustiva

7 Citas (Scopus)

Resumen

In this paper, we propose a multistage group sequential procedure to design survival trials using historical controls. The formula for the number of events required for historical control trial designs is derived. Furthermore, a transformed information time is proposed for trial monitoring. An example is given to illustrate the application of the proposed methods to survival trial designs using historical controls.

Idioma original	English
Páginas (desde-hasta)	405-411
Número de páginas	7
Publicación	Pharmaceutical Statistics
Volumen	15
N.º	5
DOI	https://doi.org/10.1002/pst.1756
Estado	Published - sept 1 2016

Nota bibliográfica

Publisher Copyright:
Copyright © 2016 John Wiley & Sons, Ltd.

Financiación

The author acknowledges anonymous reviewers and associate editor for their valuable comments that improved an earlier version of the paper. This work was supported in part by National Cancer Institute (NCI) support grant P30CA021765 and ALSAC.

Financiadores	Número del financiador
National Childhood Cancer Registry – National Cancer Institute	P30CA021765
American Lebanese Syrian Associated Charities

ASJC Scopus subject areas

Statistics and Probability
Pharmacology
Pharmacology (medical)

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10.1002/pst.1756

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KW - information time

KW - log-rank test

KW - sample size

KW - time-to-event

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Survival trial design and monitoring using historical controls

Resumen

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Financiación

ASJC Scopus subject areas

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