Resumen
Both enantiomers of modafinil, adrafinil, modafinic acid and ethyl modafinate were prepared from the diastereomers formed by reacting racemic β-sulfinyl carboxylic acid with (4R)-phenyl-thiazolidinethione. The absolute stereochemistry of the sulfoxide group was confirmed via X-ray analysis of one of the thiazolidinethione diastereomers.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 3811-3815 |
| Número de páginas | 5 |
| Publicación | Tetrahedron Asymmetry |
| Volumen | 15 |
| N.º | 23 |
| DOI | |
| Estado | Published - nov 29 2004 |
Nota bibliográfica
Funding Information:Financial support for this work was provided by the National Science Foundation (CHE-0111292 and EEC-0310689). We thank Mr. John Podobinski for the preparation of compound 4 and Dr. Dale Swenson for obtaining the crystallographic analysis of compound (−)- 5 . We are indebted to Dr. Blake Watkins (University of Mississippi) for obtaining all the HRMS.
Financiación
Financial support for this work was provided by the National Science Foundation (CHE-0111292 and EEC-0310689). We thank Mr. John Podobinski for the preparation of compound 4 and Dr. Dale Swenson for obtaining the crystallographic analysis of compound (−)- 5 . We are indebted to Dr. Blake Watkins (University of Mississippi) for obtaining all the HRMS.
| Financiadores | Número del financiador |
|---|---|
| National Science Foundation (NSF) | EEC-0310689, CHE-0111292 |
ASJC Scopus subject areas
- Catalysis
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
Huella
Profundice en los temas de investigación de 'Synthesis and determination of the absolute stereochemistry of the enantiomers of adrafinil and modafinil'. En conjunto forman una huella única.Citar esto
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver