Targeting the spliceosome

Brian Rymond

doi:10.1038/nchembio0907-533

Targeting the spliceosome

Brian Rymond

Biology

Producción científica: Short survey › revisión exhaustiva

27 Citas (Scopus)

Resumen

The U2 snRNP particle is an essential component of the eukaryotic pre-mRNA splicing apparatus, the spliceosome. Natural and semisynthetic inhibitors that bind the SF3b subunit of the U2 snRNP block splicing and prompt nuclear export of intron-bearing precursors, defining a new mode of action in anticancer drugs.

Idioma original	English
Páginas (desde-hasta)	533-535
Número de páginas	3
Publicación	Nature Chemical Biology
Volumen	3
N.º	9
DOI	https://doi.org/10.1038/nchembio0907-533
Estado	Published - sept 2007

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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Targeting the spliceosome

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