The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase

Masanori Funabashi; Satoshi Baba; Koichi Nonaka; Masahiko Hosobuchi; Yoko Fujita; Tomoyuki Shibata; Steven G. Van Lanen

doi:10.1002/cbic.200900665

The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase

Masanori Funabashi
, Satoshi Baba
, Koichi Nonaka
, Masahiko Hosobuchi
, Yoko Fujita
, Tomoyuki Shibata
, Steven G. Van Lanen

Producción científica: Article › revisión exhaustiva

55 Citas (Scopus)

Resumen

Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).

Idioma original	English
Páginas (desde-hasta)	184-190
Número de páginas	7
Publicación	ChemBioChem
Volumen	11
N.º	2
DOI	https://doi.org/10.1002/cbic.200900665
Estado	Published - ene 25 2010

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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10.1002/cbic.200900665

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title = "The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase",

abstract = "Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).",

keywords = "Antibiotics, Bacterial translocase I, Biosynthesis, Nucleosides, Sulfotransferase",

author = "Masanori Funabashi and Satoshi Baba and Koichi Nonaka and Masahiko Hosobuchi and Yoko Fujita and Tomoyuki Shibata and \{Van Lanen\}, \{Steven G.\}",

year = "2010",

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doi = "10.1002/cbic.200900665",

language = "English",

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AU - Funabashi, Masanori

AU - Baba, Satoshi

AU - Nonaka, Koichi

AU - Hosobuchi, Masahiko

AU - Fujita, Yoko

AU - Shibata, Tomoyuki

AU - Van Lanen, Steven G.

PY - 2010/1/25

Y1 - 2010/1/25

N2 - Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).

AB - Lip reading: The biosynthetic gene cluster for A-90289, a fatty acid nucleoside antibiotic, was cloned and sequenced. The sulfotransferase LipB is demonstrated to be essential for A-90289 biosynthesis, and in vitro characterization revealed LipB utilizes p-nitrophenylsulfate as an aryl sulfate donor and a variety of nonaryl acceptors including caprazamycin A to give the 2′-O-sulfated product, A-90289A. (Chemical Equation Presented).

KW - Antibiotics

KW - Bacterial translocase I

KW - Biosynthesis

KW - Nucleosides

KW - Sulfotransferase

UR - https://www.scopus.com/pages/publications/76649083231

UR - https://www.scopus.com/pages/publications/76649083231#tab=citedBy

U2 - 10.1002/cbic.200900665

DO - 10.1002/cbic.200900665

M3 - Article

C2 - 20043306

AN - SCOPUS:76649083231

SN - 1439-4227

VL - 11

SP - 184

EP - 190

JO - ChemBioChem

JF - ChemBioChem

IS - 2

ER -

The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase

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