The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Robin L. Cooper; Micaiah McNabb; Jeremy Nadolski

doi:10.1016/j.heliyon.2019.e01430

The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Robin L. Cooper
, Micaiah McNabb
, Jeremy Nadolski

Producción científica: Article › revisión exhaustiva

16 Citas (Scopus)

Resumen

The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

Idioma original	English
Número de artículo	e01430
Publicación	Heliyon
Volumen	5
N.º	3
DOI	https://doi.org/10.1016/j.heliyon.2019.e01430
Estado	Published - mar 2019

Nota bibliográfica

Publisher Copyright:
© 2019 The Authors

Financiación

This work was supported by personal funds (R.L.C.) and a “Sustaining Excellence-2014” competition grant from the Howard Hughes Medical Institute (Grant #52008116 ) awarded to the University of Kentucky (VM Cassone, PI). The authors confirm that the funder had no influence over the study design, content of the article, or selection of this journal.

Financiadores	Número del financiador
Howard Hughes Medical Institute	52008116
University of Kentucky

ASJC Scopus subject areas

General

Acceder al documento

10.1016/j.heliyon.2019.e01430

Otros archivos y enlaces

Citar esto

@article{115d78f11c484ad1ba193b7d7acd2539,

title = "The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction",

abstract = "The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.",

keywords = "Immunology, Neuroscience, Physiology, Zoology",

author = "Cooper, \{Robin L.\} and Micaiah McNabb and Jeremy Nadolski",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = mar,

doi = "10.1016/j.heliyon.2019.e01430",

language = "English",

volume = "5",

number = "3",

}

TY - JOUR

T1 - The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

AU - Cooper, Robin L.

AU - McNabb, Micaiah

AU - Nadolski, Jeremy

PY - 2019/3

Y1 - 2019/3

N2 - The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

AB - The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

KW - Immunology

KW - Neuroscience

KW - Physiology

KW - Zoology

UR - https://www.scopus.com/pages/publications/85063400703

UR - https://www.scopus.com/pages/publications/85063400703#tab=citedBy

U2 - 10.1016/j.heliyon.2019.e01430

DO - 10.1016/j.heliyon.2019.e01430

M3 - Article

AN - SCOPUS:85063400703

SN - 2405-8440

VL - 5

JO - Heliyon

JF - Heliyon

IS - 3

M1 - e01430

ER -

The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto