TY - JOUR
T1 - The immunopharmacological properties of transforming growth factor beta
AU - Le, Yingying
AU - Yu, Xiaojing
AU - Ruan, Lingfei
AU - Wang, Oumei
AU - Qi, Dongfei
AU - Zhu, Jingjing
AU - Lu, Xiaofeng
AU - Kong, Yan
AU - Cai, Kun
AU - Pang, Shanshan
AU - Shi, Xianglin
AU - Wang, Ji Ming
PY - 2005/12
Y1 - 2005/12
N2 - Transforming growth factor-β (TGF-β) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. These events are closely associated with host immune responses and inflammation. Despite some controversies on their function in controlling dendritic and T regulatory cell development and activity, the importance of TGF-βs in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. Since one of the major biological properties of TGF-βs is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions.
AB - Transforming growth factor-β (TGF-β) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. These events are closely associated with host immune responses and inflammation. Despite some controversies on their function in controlling dendritic and T regulatory cell development and activity, the importance of TGF-βs in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. Since one of the major biological properties of TGF-βs is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions.
KW - Alzheimer's disease
KW - Inflammation
KW - Transforming growth factor beta
UR - https://www.scopus.com/pages/publications/27744432242
UR - https://www.scopus.com/pages/publications/27744432242#tab=citedBy
U2 - 10.1016/j.intimp.2005.07.006
DO - 10.1016/j.intimp.2005.07.006
M3 - Review article
C2 - 16275614
AN - SCOPUS:27744432242
SN - 1567-5769
VL - 5
SP - 1771
EP - 1782
JO - International Immunopharmacology
JF - International Immunopharmacology
IS - 13-14
ER -