The influence of induced hypertension in acute phase on focal cerebral ischemia injury

Objective: To study the influence of induced hypertension in acute phase on the infarct volume and regional cerebral blood flow(rCBF) during focal cerebral ischemia in rats. Methods: The adult rat's models of permanent focal cerebral ischemia were established by permanent middle artery occlusion. Thirty-six rats were divided six groups. The rCBF of cortical penumbra during focal cerebral ischemia was determined by Laser-Doppler Flowmetry. After experiment was over, the brain was TYC stained and the infarct bolume was calculated by computer image analytic system. Results: The rCBF was resumed by (81.8 ± 3.1) %, (56.0 ± 2. 1) % Chinese source. (38.8 ± 2. 0) % in induced hypertension groups compared with the basic rCBF. The Volume of infarction was (14 ± 7) mm³, (90 ± 24) mm³ seperately in group induced hypertension after 2 and 3 hour ischemia. Induced hypertension during 3 hours could reduce infarct volume significantly. Conclusion: To improve rCBF in penumbra may be one of protective mechanism of induced hypertension on brain ischemia.