The Interaction Between Sleep and Metabolism in Alzheimer’s Disease: Cause or Consequence of Disease?

Caitlin M. Carroll; Shannon L. Macauley

doi:10.3389/fnagi.2019.00258

The Interaction Between Sleep and Metabolism in Alzheimer’s Disease: Cause or Consequence of Disease?

Caitlin M. Carroll
, Shannon L. Macauley

Producción científica: Review article › revisión exhaustiva

26 Citas (Scopus)

Resumen

Alzheimer’s disease (AD) is the most common form of dementia and affects over 45 million people worldwide. Both type-2-diabetes (T2D), a metabolic condition associated with aging, and disrupted sleep are implicated in the pathogenesis of AD, but how sleep and metabolism interact to affect AD progression remains unclear. In the healthy brain, sleep/wake cycles are a well-coordinated interaction between metabolic and neuronal activity, but when disrupted, are associated with a myriad of health-related issues, including metabolic syndrome, cardiovascular disease, T2D, and AD. Therefore, this review will explore our current understanding of the relationship between metabolism, sleep, and AD-related pathology to identify the causes and consequences of disease progression in AD. Moreover, sleep disturbances and metabolic dysfunction could serve as potential therapeutic targets to mitigate the increased risk of AD in individuals with T2D or offer a novel approach for treating AD.

Idioma original	English
Número de artículo	258
Publicación	Frontiers in Aging Neuroscience
Volumen	11
DOI	https://doi.org/10.3389/fnagi.2019.00258
Estado	Published - sept 20 2019

Nota bibliográfica

Publisher Copyright:
© Copyright © 2019 Carroll and Macauley.

Financiación

The authors would like to thank their colleagues for the careful review and critique of this manuscript. Funding. We would like to acknowledge the following grants: 1K01AG050719 (SM), R01AG061805 (SM), NCDRC Pilot Award (SM), and the Wake Forest University Alzheimer’s Disease Research Center (P30 AG049638), which is funded by the National Institute on Aging.

Financiadores	Número del financiador
NCDRC
National Institute on Aging
Alzheimer's Disease Research Center, Wake Forest School of Medicine	P30 AG049638
Alzheimer's Disease Research Center, Wake Forest School of Medicine

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Aging
Cognitive Neuroscience

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title = "The Interaction Between Sleep and Metabolism in Alzheimer{\textquoteright}s Disease: Cause or Consequence of Disease?",

abstract = "Alzheimer{\textquoteright}s disease (AD) is the most common form of dementia and affects over 45 million people worldwide. Both type-2-diabetes (T2D), a metabolic condition associated with aging, and disrupted sleep are implicated in the pathogenesis of AD, but how sleep and metabolism interact to affect AD progression remains unclear. In the healthy brain, sleep/wake cycles are a well-coordinated interaction between metabolic and neuronal activity, but when disrupted, are associated with a myriad of health-related issues, including metabolic syndrome, cardiovascular disease, T2D, and AD. Therefore, this review will explore our current understanding of the relationship between metabolism, sleep, and AD-related pathology to identify the causes and consequences of disease progression in AD. Moreover, sleep disturbances and metabolic dysfunction could serve as potential therapeutic targets to mitigate the increased risk of AD in individuals with T2D or offer a novel approach for treating AD.",

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KW - glucose

KW - insulin

KW - metabolism

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KW - type-2-diabetes

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The Interaction Between Sleep and Metabolism in Alzheimer’s Disease: Cause or Consequence of Disease?

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

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Huella

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