@inbook{304385b421fa4cc59cc959d7fc27a90a,
title = "The mouse digit tip: From wound healing to regeneration",
abstract = "A challenge to the study of regeneration is determining at what point the processes of wound healing and regeneration diverge. The mouse displays level-specific regeneration responses. An amputation through the distal third of the terminal phalanx will prompt a regeneration response and result in a new digit tip that mimics the morphology of the lost digit tip. Conversely, an amputation through the distal third of the intermediate phalanx initiates a wound healing and scarring response. The mouse, therefore, provides a model for studying the transition between wound healing and regeneration in the same animal. This chapter details the methods used in the study of mammalian digit regeneration, including a method to introduce exogenous protein into the mouse digit amputation model via microcarrier beads and methods for analysis of bone regeneration.",
keywords = "Amputation model, Digit regeneration, Scarring response",
author = "Jennifer Simkin and Manjong Han and Ling Yu and Mingquan Yan and Ken Muneoka",
year = "2013",
doi = "10.1007/978-1-62703-505-7\_24",
language = "English",
isbn = "9781627035040",
series = "Methods in Molecular Biology",
pages = "419--435",
booktitle = "Wound Regeneration and Repair",
}