The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones

Guangrong Zheng; Linda P. Dwoskin; Peter A. Crooks

doi:10.1081/SCC-120037905

The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones

Guangrong Zheng, Linda P. Dwoskin, Peter A. Crooks

Producción científica: Article › revisión exhaustiva

9 Citas (Scopus)

Resumen

An efficient and versatile two-step synthesis of 2-arylmethylidene-8- methyl-8-azabicyclo[3.2.1]octane-3-ones, via mono aldol condensation of tropinone with a variety of aryl aldehydes followed by pTsOH-catalyzed dehydration, is described.

Idioma original	English
Páginas (desde-hasta)	1931-1942
Número de páginas	12
Publicación	Synthetic Communications
Volumen	34
N.º	11
DOI	https://doi.org/10.1081/SCC-120037905
Estado	Published - 2004

Nota bibliográfica

Funding Information:
This research was supported by National Institute of Health grants DA13519 and DA00399. High resolution mass spectral determinations were carried out at the University of Kentucky Mass Spectrometry Facility.

Financiación

This research was supported by National Institute of Health grants DA13519 and DA00399. High resolution mass spectral determinations were carried out at the University of Kentucky Mass Spectrometry Facility.

Financiadores	Número del financiador
National Institute of Health National Institute of Minority and Health Disparities Loan Repayment Program	DA13519, DA00399

ASJC Scopus subject areas

Organic Chemistry

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10.1081/SCC-120037905

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title = "The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones",

abstract = "An efficient and versatile two-step synthesis of 2-arylmethylidene-8- methyl-8-azabicyclo[3.2.1]octane-3-ones, via mono aldol condensation of tropinone with a variety of aryl aldehydes followed by pTsOH-catalyzed dehydration, is described.",

keywords = "Aldol condensation, CNS agents, THF, Tropane analogs",

author = "Guangrong Zheng and Dwoskin, \{Linda P.\} and Crooks, \{Peter A.\}",

note = "Funding Information: This research was supported by National Institute of Health grants DA13519 and DA00399. High resolution mass spectral determinations were carried out at the University of Kentucky Mass Spectrometry Facility.",

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doi = "10.1081/SCC-120037905",

language = "English",

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T1 - The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones

AU - Zheng, Guangrong

AU - Dwoskin, Linda P.

AU - Crooks, Peter A.

N1 - Funding Information: This research was supported by National Institute of Health grants DA13519 and DA00399. High resolution mass spectral determinations were carried out at the University of Kentucky Mass Spectrometry Facility.

PY - 2004

Y1 - 2004

N2 - An efficient and versatile two-step synthesis of 2-arylmethylidene-8- methyl-8-azabicyclo[3.2.1]octane-3-ones, via mono aldol condensation of tropinone with a variety of aryl aldehydes followed by pTsOH-catalyzed dehydration, is described.

AB - An efficient and versatile two-step synthesis of 2-arylmethylidene-8- methyl-8-azabicyclo[3.2.1]octane-3-ones, via mono aldol condensation of tropinone with a variety of aryl aldehydes followed by pTsOH-catalyzed dehydration, is described.

KW - Aldol condensation

KW - CNS agents

KW - THF

KW - Tropane analogs

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U2 - 10.1081/SCC-120037905

DO - 10.1081/SCC-120037905

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SP - 1931

EP - 1942

JO - Synthetic Communications

JF - Synthetic Communications

IS - 11

ER -

The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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