The role of caveolae and caveolin in vesicle-dependent and vesicle-independent trafficking

Sergey Matveev; Xiangan Li; William Everson; Eric J. Smart

doi:10.1016/S0169-409X(01)00138-7

The role of caveolae and caveolin in vesicle-dependent and vesicle-independent trafficking

Sergey Matveev
, Xiangan Li
, William Everson
, Eric J. Smart

Physiology

Producción científica: Review article › revisión exhaustiva

90 Citas (Scopus)

Resumen

Caveolae can mediate endocytosis, transcytosis, and potocytosis. Our understanding of these processes as well as the elucidation of the molecular machinery involved has greatly expanded. In addition, caveolin, a 22 kDa protein often associated with caveolae, can promote the trafficking of sterol through the cytoplasm independent of vesicles. Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes.

Idioma original	English
Páginas (desde-hasta)	237-250
Número de páginas	14
Publicación	Advanced Drug Delivery Reviews
Volumen	49
N.º	3
DOI	https://doi.org/10.1016/S0169-409X(01)00138-7
Estado	Published - jul 28 2001

Nota bibliográfica

Funding Information:
This work was supported by NIH grants HL58475, HL62844, and HL64056 (EJS).

Financiación

This work was supported by NIH grants HL58475, HL62844, and HL64056 (EJS).

Financiadores	Número del financiador
National Institutes of Health (NIH)	HL62844, HL64056
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute Family Blood Pressure Program	R01HL058475
National Heart, Lung, and Blood Institute Family Blood Pressure Program

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Pharmaceutical Science

Acceder al documento

10.1016/S0169-409X(01)00138-7

Otros archivos y enlaces

Citar esto

@article{6c516354cc05490c824a97ff96113ac9,

title = "The role of caveolae and caveolin in vesicle-dependent and vesicle-independent trafficking",

abstract = "Caveolae can mediate endocytosis, transcytosis, and potocytosis. Our understanding of these processes as well as the elucidation of the molecular machinery involved has greatly expanded. In addition, caveolin, a 22 kDa protein often associated with caveolae, can promote the trafficking of sterol through the cytoplasm independent of vesicles. Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes.",

keywords = "Cholera toxin, Cholesterol, Endocytosis, Potocytosis, Trafficking, Transcytosis",

author = "Sergey Matveev and Xiangan Li and William Everson and Smart, \{Eric J.\}",

note = "Funding Information: This work was supported by NIH grants HL58475, HL62844, and HL64056 (EJS).",

year = "2001",

month = jul,

day = "28",

doi = "10.1016/S0169-409X(01)00138-7",

language = "English",

volume = "49",

pages = "237--250",

number = "3",

}

TY - JOUR

T1 - The role of caveolae and caveolin in vesicle-dependent and vesicle-independent trafficking

AU - Matveev, Sergey

AU - Li, Xiangan

AU - Everson, William

AU - Smart, Eric J.

N1 - Funding Information: This work was supported by NIH grants HL58475, HL62844, and HL64056 (EJS).

PY - 2001/7/28

Y1 - 2001/7/28

N2 - Caveolae can mediate endocytosis, transcytosis, and potocytosis. Our understanding of these processes as well as the elucidation of the molecular machinery involved has greatly expanded. In addition, caveolin, a 22 kDa protein often associated with caveolae, can promote the trafficking of sterol through the cytoplasm independent of vesicles. Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes.

AB - Caveolae can mediate endocytosis, transcytosis, and potocytosis. Our understanding of these processes as well as the elucidation of the molecular machinery involved has greatly expanded. In addition, caveolin, a 22 kDa protein often associated with caveolae, can promote the trafficking of sterol through the cytoplasm independent of vesicles. Caveolin also influences the formation, morphology, and function of caveolae. The ability of caveolae and caveolin to mediate macromolecular transport directly impacts a variety of physiological and pathophysiological processes.

KW - Cholera toxin

KW - Cholesterol

KW - Endocytosis

KW - Potocytosis

KW - Trafficking

KW - Transcytosis

UR - https://www.scopus.com/pages/publications/0035963866

UR - https://www.scopus.com/pages/publications/0035963866#tab=citedBy

U2 - 10.1016/S0169-409X(01)00138-7

DO - 10.1016/S0169-409X(01)00138-7

M3 - Review article

C2 - 11551397

AN - SCOPUS:0035963866

SN - 0169-409X

VL - 49

SP - 237

EP - 250

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

IS - 3

ER -

The role of caveolae and caveolin in vesicle-dependent and vesicle-independent trafficking

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto