TY - JOUR
T1 - Thiol-Modulating Agents Increase Manganese Superoxide Dismutase Activity in Human Lung Fibroblasts
AU - Wan, X. Steven
AU - St. Clair, Daret K.
PY - 1993
Y1 - 1993
N2 - The effect of three thiol-modulating agents, buthionine sulfoximine (BSO), N-ethylmaleimide (NEM), and diazenedicarboxylic acid bis(N, N′-dimethylamide) (diamide), on cellular glutathione (GSH) level and manganese superoxide dismutase (MnSOD) activity was studied in a human lung fibroblast cell line, WI38. The results showed that treatment with BSO, NEM, or diamide can increase MnSOD activity in the human fibroblast cells. These findings are compatible with the view that alteration of intracellular GSH level may create a pro-oxidant environment in the cells and the MnSOD activity may increase as a cellular response to the oxidative stress.
AB - The effect of three thiol-modulating agents, buthionine sulfoximine (BSO), N-ethylmaleimide (NEM), and diazenedicarboxylic acid bis(N, N′-dimethylamide) (diamide), on cellular glutathione (GSH) level and manganese superoxide dismutase (MnSOD) activity was studied in a human lung fibroblast cell line, WI38. The results showed that treatment with BSO, NEM, or diamide can increase MnSOD activity in the human fibroblast cells. These findings are compatible with the view that alteration of intracellular GSH level may create a pro-oxidant environment in the cells and the MnSOD activity may increase as a cellular response to the oxidative stress.
UR - https://www.scopus.com/pages/publications/0027293061
UR - https://www.scopus.com/pages/publications/0027293061#tab=citedBy
U2 - 10.1006/abbi.1993.1325
DO - 10.1006/abbi.1993.1325
M3 - Article
C2 - 8323302
AN - SCOPUS:0027293061
SN - 0003-9861
VL - 304
SP - 89
EP - 93
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
IS - 1
ER -