TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion

Y. Wu; B. P. Zhou

doi:10.1038/sj.bjc.6605530

TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion

Y. Wu
, B. P. Zhou

Producción científica: Short survey › revisión exhaustiva

748 Citas (SciVal)

Resumen

Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.

Idioma original	English
Páginas (desde-hasta)	639-644
Número de páginas	6
Publicación	British Journal of Cancer
Volumen	102
N.º	4
DOI	https://doi.org/10.1038/sj.bjc.6605530
Estado	Published - feb 2010

Nota bibliográfica

Funding Information:
We apologize to the many contributors of this field whose work is important but that we were unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G Komen Foundation (KG081310) and the Mary Kay Ash Foundation(to BP Zhou).

Financiación

We apologize to the many contributors of this field whose work is important but that we were unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G Komen Foundation (KG081310) and the Mary Kay Ash Foundation(to BP Zhou).

Financiadores	Número del financiador
Susan G Komen Foundation	KG081310
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute	R01CA125454
National Childhood Cancer Registry – National Cancer Institute
Mary Kay Ash Foundation

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/sj.bjc.6605530

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title = "TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion",

abstract = "Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.",

keywords = "EMT, NF-κB, Snail, TNF-α",

author = "Y. Wu and Zhou, \{B. P.\}",

note = "Funding Information: We apologize to the many contributors of this field whose work is important but that we were unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G Komen Foundation (KG081310) and the Mary Kay Ash Foundation(to BP Zhou).",

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AU - Wu, Y.

AU - Zhou, B. P.

N1 - Funding Information: We apologize to the many contributors of this field whose work is important but that we were unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G Komen Foundation (KG081310) and the Mary Kay Ash Foundation(to BP Zhou).

PY - 2010/2

Y1 - 2010/2

N2 - Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.

AB - Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.

KW - EMT

KW - NF-κB

KW - Snail

KW - TNF-α

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DO - 10.1038/sj.bjc.6605530

M3 - Short survey

C2 - 20087353

AN - SCOPUS:76949084622

SN - 0007-0920

VL - 102

SP - 639

EP - 644

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 4

ER -

TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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