TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: Links to HIV-1-associated dementia

Lisa A. Ryan; Hui Peng; David A. Erichsen; Yunlong Huang; Yuri Persidsky; You Zhou; Howard E. Gendelman; Jialin Zheng

doi:10.1016/j.jneuroim.2003.11.019

TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: Links to HIV-1-associated dementia

Lisa A. Ryan, Hui Peng, David A. Erichsen, Yunlong Huang, Yuri Persidsky, You Zhou, Howard E. Gendelman, Jialin Zheng

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

57 Citas (Scopus)

Resumen

TNF-related apoptosis-inducing ligand (TRAIL) is a type II integral membrane protein that interacts with multiple receptors and cell types including neurons. In this report, TRAIL protein levels were increased in human monocyte-derived macrophages (MDM) after HIV-1 infection and immune activation. In HIV-1 encephalitic (HIVE) human brain tissue, TRAIL-expressing macrophages were found in association with active caspase-3 positive neurons. Cytotoxic TRAIL receptors 1 and 2 were expressed on neurons in primary human fetal cultures and HIV-1 encephalitic brain tissue. Furthermore, TRAIL induced a dose-dependent effect on neuronal apoptosis. These results support a role for TRAIL in mononuclear phagocyte (MP)-mediated neurotoxicity in HIV-1-associated dementia (HAD).

Idioma original	English
Páginas (desde-hasta)	127-139
Número de páginas	13
Publicación	Journal of Neuroimmunology
Volumen	148
N.º	1-2
DOI	https://doi.org/10.1016/j.jneuroim.2003.11.019
Estado	Published - mar 2004

Nota bibliográfica

Funding Information:
This work was supported in part by research grants by the National Institutes of Health: R01 NS 41858-01 (JZ), P20 RR15635-01 (JZ and HEG) and P01 NS043985-01 (HEG and JZ). We kindly acknowledge Dr. Anuja Ghorpade for scientific support and fruitful discussion. Li Wu, David Heilman, Jiaxing Zhao, Alicia Lopez, Clancy McNally and Abby Cheloha provided technical support for this work. Ms. Shelley Herek, Mr. Nathan Erdmann, Dr. Kim Carlson and Dr. Jenae Limoges provided valuable comments and suggestions about the manuscript. Dr. Charles Kuszynski and Linda Wilkie performed the FACS analyses. Julie Ditter and Myhanh Che provided outstanding administrative support. Ms. Robin Taylor's contribution for providing outstanding support in assembling the work for publication is appreciated.

Financiación

This work was supported in part by research grants by the National Institutes of Health: R01 NS 41858-01 (JZ), P20 RR15635-01 (JZ and HEG) and P01 NS043985-01 (HEG and JZ). We kindly acknowledge Dr. Anuja Ghorpade for scientific support and fruitful discussion. Li Wu, David Heilman, Jiaxing Zhao, Alicia Lopez, Clancy McNally and Abby Cheloha provided technical support for this work. Ms. Shelley Herek, Mr. Nathan Erdmann, Dr. Kim Carlson and Dr. Jenae Limoges provided valuable comments and suggestions about the manuscript. Dr. Charles Kuszynski and Linda Wilkie performed the FACS analyses. Julie Ditter and Myhanh Che provided outstanding administrative support. Ms. Robin Taylor's contribution for providing outstanding support in assembling the work for publication is appreciated.

Financiadores	Número del financiador
National Institutes of Health (NIH)	P20 RR15635-01, R01 NS 41858-01, P01 NS043985-01
National Institute of Neurological Disorders and Stroke	R01NS041858

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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10.1016/j.jneuroim.2003.11.019

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title = "TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: Links to HIV-1-associated dementia",

abstract = "TNF-related apoptosis-inducing ligand (TRAIL) is a type II integral membrane protein that interacts with multiple receptors and cell types including neurons. In this report, TRAIL protein levels were increased in human monocyte-derived macrophages (MDM) after HIV-1 infection and immune activation. In HIV-1 encephalitic (HIVE) human brain tissue, TRAIL-expressing macrophages were found in association with active caspase-3 positive neurons. Cytotoxic TRAIL receptors 1 and 2 were expressed on neurons in primary human fetal cultures and HIV-1 encephalitic brain tissue. Furthermore, TRAIL induced a dose-dependent effect on neuronal apoptosis. These results support a role for TRAIL in mononuclear phagocyte (MP)-mediated neurotoxicity in HIV-1-associated dementia (HAD).",

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author = "Ryan, \{Lisa A.\} and Hui Peng and Erichsen, \{David A.\} and Yunlong Huang and Yuri Persidsky and You Zhou and Gendelman, \{Howard E.\} and Jialin Zheng",

note = "Funding Information: This work was supported in part by research grants by the National Institutes of Health: R01 NS 41858-01 (JZ), P20 RR15635-01 (JZ and HEG) and P01 NS043985-01 (HEG and JZ). We kindly acknowledge Dr. Anuja Ghorpade for scientific support and fruitful discussion. Li Wu, David Heilman, Jiaxing Zhao, Alicia Lopez, Clancy McNally and Abby Cheloha provided technical support for this work. Ms. Shelley Herek, Mr. Nathan Erdmann, Dr. Kim Carlson and Dr. Jenae Limoges provided valuable comments and suggestions about the manuscript. Dr. Charles Kuszynski and Linda Wilkie performed the FACS analyses. Julie Ditter and Myhanh Che provided outstanding administrative support. Ms. Robin Taylor's contribution for providing outstanding support in assembling the work for publication is appreciated. ",

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AU - Huang, Yunlong

AU - Persidsky, Yuri

AU - Zhou, You

AU - Gendelman, Howard E.

AU - Zheng, Jialin

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KW - HIV-1 encephalitis

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TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: Links to HIV-1-associated dementia

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

Acceder al documento

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