Tooth Loss, apolipoprotein E, and decline in delayed word recall

P. S. Stein; R. J. Kryscio; M. Desrosiers; S. J. Donegan; M. B. Gibbs

doi:10.1177/0022034509357881

Tooth Loss, apolipoprotein E, and decline in delayed word recall

P. S. Stein
, R. J. Kryscio
, M. Desrosiers
, S. J. Donegan
, M. B. Gibbs

Producción científica: Article › revisión exhaustiva

69 Citas (Scopus)

Resumen

Our previous research suggests an association between a low number of teeth and increased risk of dementia. The aim of the present study was to determine if a low number of teeth is specifically related to memory decline as evidenced by low Delayed Word Recall scores. In addition, we examined the combined effect of a low number of teeth and the apolipoprotein E ε4 allele on Delayed Word Recall scores. We hypothesized that the scores of those who had the allele and a low number of teeth (0-9) would decline more rapidly over time than those participants with a greater number of teeth who lacked the allele. We found that individuals with both risk factors (the allele and fewer teeth) had lower Delayed Word Recall scores at the first examination and declined more quickly compared with participants with neither of these risk factors or with either risk factor alone.

Idioma original	English
Páginas (desde-hasta)	473-477
Número de páginas	5
Publicación	Journal of Dental Research
Volumen	89
N.º	5
DOI	https://doi.org/10.1177/0022034509357881
Estado	Published - may 2010

Nota bibliográfica

Funding Information:
Funding for this research was provided by grants from the U.S. National Institute on Aging: R01AG09862, K04AG00553, and 1P30AG028383, from the Abercrombie Foundation and Kleberg Foundation, from the National Center for Research Resources, a component of the National Institutes of Health: P20 RR020145 and from a K30 grant: K30HL04163. Further information about the Nun Study may be found at www.nunstudy.org .

Financiación

Funding for this research was provided by grants from the U.S. National Institute on Aging: R01AG09862, K04AG00553, and 1P30AG028383, from the Abercrombie Foundation and Kleberg Foundation, from the National Center for Research Resources, a component of the National Institutes of Health: P20 RR020145 and from a K30 grant: K30HL04163. Further information about the Nun Study may be found at www.nunstudy.org .

Financiadores	Número del financiador
National Institutes of Health (NIH)	P20 RR020145
National Institutes of Health (NIH)
National Institute on Aging	K04AG00553, R01AG09862, 1P30AG028383
National Institute on Aging
National Heart, Lung, and Blood Institute (NHLBI)	K30HL004163
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Research Resources
Abercrombie Foundation
Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation

ASJC Scopus subject areas

General Dentistry

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title = "Tooth Loss, apolipoprotein E, and decline in delayed word recall",

abstract = "Our previous research suggests an association between a low number of teeth and increased risk of dementia. The aim of the present study was to determine if a low number of teeth is specifically related to memory decline as evidenced by low Delayed Word Recall scores. In addition, we examined the combined effect of a low number of teeth and the apolipoprotein E ε4 allele on Delayed Word Recall scores. We hypothesized that the scores of those who had the allele and a low number of teeth (0-9) would decline more rapidly over time than those participants with a greater number of teeth who lacked the allele. We found that individuals with both risk factors (the allele and fewer teeth) had lower Delayed Word Recall scores at the first examination and declined more quickly compared with participants with neither of these risk factors or with either risk factor alone.",

keywords = "Apolipoprotein E ε4, Cognition., Delayed word recall, Memory, Teeth",

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AU - Donegan, S. J.

AU - Gibbs, M. B.

N1 - Funding Information: Funding for this research was provided by grants from the U.S. National Institute on Aging: R01AG09862, K04AG00553, and 1P30AG028383, from the Abercrombie Foundation and Kleberg Foundation, from the National Center for Research Resources, a component of the National Institutes of Health: P20 RR020145 and from a K30 grant: K30HL04163. Further information about the Nun Study may be found at www.nunstudy.org .

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N2 - Our previous research suggests an association between a low number of teeth and increased risk of dementia. The aim of the present study was to determine if a low number of teeth is specifically related to memory decline as evidenced by low Delayed Word Recall scores. In addition, we examined the combined effect of a low number of teeth and the apolipoprotein E ε4 allele on Delayed Word Recall scores. We hypothesized that the scores of those who had the allele and a low number of teeth (0-9) would decline more rapidly over time than those participants with a greater number of teeth who lacked the allele. We found that individuals with both risk factors (the allele and fewer teeth) had lower Delayed Word Recall scores at the first examination and declined more quickly compared with participants with neither of these risk factors or with either risk factor alone.

AB - Our previous research suggests an association between a low number of teeth and increased risk of dementia. The aim of the present study was to determine if a low number of teeth is specifically related to memory decline as evidenced by low Delayed Word Recall scores. In addition, we examined the combined effect of a low number of teeth and the apolipoprotein E ε4 allele on Delayed Word Recall scores. We hypothesized that the scores of those who had the allele and a low number of teeth (0-9) would decline more rapidly over time than those participants with a greater number of teeth who lacked the allele. We found that individuals with both risk factors (the allele and fewer teeth) had lower Delayed Word Recall scores at the first examination and declined more quickly compared with participants with neither of these risk factors or with either risk factor alone.

KW - Apolipoprotein E ε4

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KW - Memory

KW - Teeth

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Tooth Loss, apolipoprotein E, and decline in delayed word recall

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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