Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice

Yoshiro Naito; Hisashi Sawada; Tetsuo Horimatsu; Masaki Ohmuraya; Masanori Asakura; Masaharu Ishihara

doi:10.1038/s41440-025-02254-4

Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice

Yoshiro Naito
, Hisashi Sawada
, Tetsuo Horimatsu
, Masaki Ohmuraya
, Masanori Asakura
, Masaharu Ishihara

Producción científica: Article › revisión exhaustiva

Resumen

Transferrin receptor 1 (TfR1), a crucial cellular iron receptor, has a variety of biological functions. We have previously reported that TfR1 abundance increases in the aortic media of hypertensive rat models. However, its role in vascular diseases remains unknown. In the present study, we generated smooth muscle cell (SMC)-specific TfR1 deficient mice and examined the impact of its deletion in mouse models of hypertension induced by angiotensin II or deoxycorticosterone acetate/salt administration. SMC-specific TfR1 deletion attenuated medial thickening and elastin fragmentation in both mouse models of hypertension. These results indicate that TfR1 in SMCs exerts a role in vascular remodeling in hypertension. (Figure presented.)

Idioma original	English
Páginas (desde-hasta)	2263-2268
Número de páginas	6
Publicación	Hypertension Research
Volumen	48
N.º	8
DOI	https://doi.org/10.1038/s41440-025-02254-4
Estado	Published - ago 2025

Nota bibliográfica

Publisher Copyright:
© The Author(s) 2025.

Financiación

This work was supported by a Grant-in-Aid for Scientific Research (C) JSPS KAKENHI (#25460919, #16K09273, #19K07950, #22K07408) and grants from The Salt Science Research Foundation (#1544, #1641, #1826, and #2134) to Naito Y.

Financiadores	Número del financiador
Japan Society for the Promotion of Science	22K07408, 25460919, 16K09273, 19K07950
Salt Science Research Foundation	1544, 1641, 2134, 1826

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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10.1038/s41440-025-02254-4

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title = "Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice",

abstract = "Transferrin receptor 1 (TfR1), a crucial cellular iron receptor, has a variety of biological functions. We have previously reported that TfR1 abundance increases in the aortic media of hypertensive rat models. However, its role in vascular diseases remains unknown. In the present study, we generated smooth muscle cell (SMC)-specific TfR1 deficient mice and examined the impact of its deletion in mouse models of hypertension induced by angiotensin II or deoxycorticosterone acetate/salt administration. SMC-specific TfR1 deletion attenuated medial thickening and elastin fragmentation in both mouse models of hypertension. These results indicate that TfR1 in SMCs exerts a role in vascular remodeling in hypertension. (Figure presented.)",

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author = "Yoshiro Naito and Hisashi Sawada and Tetsuo Horimatsu and Masaki Ohmuraya and Masanori Asakura and Masaharu Ishihara",

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AU - Naito, Yoshiro

AU - Sawada, Hisashi

AU - Horimatsu, Tetsuo

AU - Ohmuraya, Masaki

AU - Asakura, Masanori

AU - Ishihara, Masaharu

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/8

Y1 - 2025/8

N2 - Transferrin receptor 1 (TfR1), a crucial cellular iron receptor, has a variety of biological functions. We have previously reported that TfR1 abundance increases in the aortic media of hypertensive rat models. However, its role in vascular diseases remains unknown. In the present study, we generated smooth muscle cell (SMC)-specific TfR1 deficient mice and examined the impact of its deletion in mouse models of hypertension induced by angiotensin II or deoxycorticosterone acetate/salt administration. SMC-specific TfR1 deletion attenuated medial thickening and elastin fragmentation in both mouse models of hypertension. These results indicate that TfR1 in SMCs exerts a role in vascular remodeling in hypertension. (Figure presented.)

AB - Transferrin receptor 1 (TfR1), a crucial cellular iron receptor, has a variety of biological functions. We have previously reported that TfR1 abundance increases in the aortic media of hypertensive rat models. However, its role in vascular diseases remains unknown. In the present study, we generated smooth muscle cell (SMC)-specific TfR1 deficient mice and examined the impact of its deletion in mouse models of hypertension induced by angiotensin II or deoxycorticosterone acetate/salt administration. SMC-specific TfR1 deletion attenuated medial thickening and elastin fragmentation in both mouse models of hypertension. These results indicate that TfR1 in SMCs exerts a role in vascular remodeling in hypertension. (Figure presented.)

KW - Smooth muscle cell

KW - Transferrin receptor 1

KW - Vascular remodeling

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DO - 10.1038/s41440-025-02254-4

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Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice

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