TRH test, DST, and response to desipramine in primary degenerative dementia

T. W. McAllister; L. R. Hays

doi:10.1016/0006-3223(87)90229-0

TRH test, DST, and response to desipramine in primary degenerative dementia

T. W. McAllister
, L. R. Hays

Producción científica: Article › revisión exhaustiva

13 Citas (Scopus)

Resumen

The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.

Idioma original	English
Páginas (desde-hasta)	189-193
Número de páginas	5
Publicación	Biological Psychiatry
Volumen	22
N.º	2
DOI	https://doi.org/10.1016/0006-3223(87)90229-0
Estado	Published - feb 1987

Nota bibliográfica

Funding Information:
From the Lexington VAMC and the University of Kentucky College of Medicine, Lexington, KY. Supported in part by the University of Kentucky ColIege of Medicine PSP Fond and VA Grant 596-073-46-61 W-01. A&SS reprint requests to: T. W. McAWer, M.D., ClmW Director, ~~~yeh~ Service, Hospital of the University of Peonsyly~ia, 11th Floor Gates Pavilion, 3400 Spruce Street, ~l~ia, 19104. Received March 24, 1986; revised July 14, 1986.

Financiación

From the Lexington VAMC and the University of Kentucky College of Medicine, Lexington, KY. Supported in part by the University of Kentucky ColIege of Medicine PSP Fond and VA Grant 596-073-46-61 W-01. A&SS reprint requests to: T. W. McAWer, M.D., ClmW Director, ~~~yeh~ Service, Hospital of the University of Peonsyly~ia, 11th Floor Gates Pavilion, 3400 Spruce Street, ~l~ia, 19104. Received March 24, 1986; revised July 14, 1986.

Financiadores	Número del financiador
University of Kentucky ColIege of Medicine PSP Fond and VA	596-073-46-61 W-01

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(87)90229-0

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title = "TRH test, DST, and response to desipramine in primary degenerative dementia",

abstract = "The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.",

author = "McAllister, \{T. W.\} and Hays, \{L. R.\}",

note = "Funding Information: From the Lexington VAMC and the University of Kentucky College of Medicine, Lexington, KY. Supported in part by the University of Kentucky ColIege of Medicine PSP Fond and VA Grant 596-073-46-61 W-01. A\&SS reprint requests to: T. W. McAWer, M.D., ClmW Director, \textasciitilde{}\textasciitilde{}\textasciitilde{}yeh\textasciitilde{} Service, Hospital of the University of Peonsyly\textasciitilde{}ia, 11th Floor Gates Pavilion, 3400 Spruce Street, \textasciitilde{}l\textasciitilde{}ia, 19104. Received March 24, 1986; revised July 14, 1986.",

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doi = "10.1016/0006-3223(87)90229-0",

language = "English",

volume = "22",

pages = "189--193",

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T1 - TRH test, DST, and response to desipramine in primary degenerative dementia

AU - McAllister, T. W.

AU - Hays, L. R.

N1 - Funding Information: From the Lexington VAMC and the University of Kentucky College of Medicine, Lexington, KY. Supported in part by the University of Kentucky ColIege of Medicine PSP Fond and VA Grant 596-073-46-61 W-01. A&SS reprint requests to: T. W. McAWer, M.D., ClmW Director, ~~~yeh~ Service, Hospital of the University of Peonsyly~ia, 11th Floor Gates Pavilion, 3400 Spruce Street, ~l~ia, 19104. Received March 24, 1986; revised July 14, 1986.

PY - 1987/2

Y1 - 1987/2

N2 - The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.

AB - The relationship of primary degenerative dementia (PDD) to major depressive disorder (MDD) is important clinically and theoretically. Neuroendocrine challenge strategies in PDD have focused primarily on the hypothalamic-pituitary-adrenal axis, have had varied results, and have not been coupled with assessment of response to antidepressant therapy. We studied the Thyrotropin-Releasing Hormone (TRH) test, the Dexamethasone Suppression Test (DST), and response to desipramine in 12 patients with PDD and 10 patients with MDD. The PDD patients had a high percentage of abnormal TRH tests and DSTs. This was not associated with improvement on desipramine.

UR - https://www.scopus.com/pages/publications/0023074827

UR - https://www.scopus.com/pages/publications/0023074827#tab=citedBy

U2 - 10.1016/0006-3223(87)90229-0

DO - 10.1016/0006-3223(87)90229-0

M3 - Article

C2 - 3101756

AN - SCOPUS:0023074827

SN - 0006-3223

VL - 22

SP - 189

EP - 193

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 2

ER -

TRH test, DST, and response to desipramine in primary degenerative dementia

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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