Tumor Necrosis Factor Receptors: A Brief Digestion

Y. Lin; B. P. Zhou

doi:10.1016/B978-0-12-394447-4.30006-2

Tumor Necrosis Factor Receptors: A Brief Digestion

Y. Lin
, B. P. Zhou

Producción científica: Chapter › revisión exhaustiva

Resumen

Members of the tumor necrosis factor receptor superfamily (TNFRSF) play essential roles in tissue development and homeostasis. Through unique receptor-ligand interaction, TNFRSF members become activated and recruit intracellular adaptor proteins to initiate diverse signaling pathways mediating cell survival, proliferation, differentiation, and apoptosis. Deregulation of TNFR pathways is associated with inflammatory and autoimmune disorders as well as cancer. Therapeutic strategies of targeting TNFRSF members and their ligands have been developed.

Idioma original	English
Título de la publicación alojada	Functional Cell Biology
Páginas	61-66
Número de páginas	6
Volumen	3
ISBN (versión digital)	9780123944474
DOI	https://doi.org/10.1016/B978-0-12-394447-4.30006-2
Estado	Published - 2016

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Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

General Medicine

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ER -

Tumor Necrosis Factor Receptors: A Brief Digestion

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