Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review

Amos Olalekan Akinyemi; Kendall Elizabeth Simpson; Sunday Faith Oyelere; Maria Nur; Chrispus Mutuku Ngule; Bolaji Charles Dayo Owoyemi; Vivian Adiila Ayarick; Felix Femi Oyelami; Oluwafunminiyi Obaleye; Dave Preston Esoe; Xiaoqi Liu; Zhiguo Li

doi:10.1186/s10020-023-00706-6

Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review

Amos Olalekan Akinyemi
, Kendall Elizabeth Simpson
, Sunday Faith Oyelere
, Maria Nur
, Chrispus Mutuku Ngule
, Bolaji Charles Dayo Owoyemi
, Vivian Adiila Ayarick
, Felix Femi Oyelami
, Oluwafunminiyi Obaleye
, Dave Preston Esoe
, Xiaoqi Liu
, Zhiguo Li

Producción científica: Review article › revisión exhaustiva

74 Citas (Scopus)

Resumen

Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to the cell surface (csGRP78) were it interacts with different ligands to initiate various intracellular pathways. The expression of csGRP78 has been associated with tumor initiation and progression of multiple cancer types. This review provides a comprehensive analysis of the existing evidence on the roles of GRP78 in various types of cancer and other human pathology. Additionally, the review discusses the current understanding of the mechanisms underlying GRP78's involvement in tumorigenesis and cancer advancement. Furthermore, we highlight recent innovative approaches employed in downregulating GRP78 expression in cancers as a potential therapeutic target.

Idioma original	English
Número de artículo	112
Publicación	Molecular Medicine
Volumen	29
N.º	1
DOI	https://doi.org/10.1186/s10020-023-00706-6
Estado	Published - dic 2023

Nota bibliográfica

Publisher Copyright:
© 2023, The Feinstein Institute for Medical Research.

Financiación

The work was generously supported by the National Institutes of Health (NIH) (No. R01 CA266579 to Zhiguo Li) and partially supported by the UK CARES Career Development Program (No. P30ES026529) and the American Cancer Society (No. IRG 19–140-31).

Financiadores	Número del financiador
UK-CARES	P30ES026529
National Institutes of Health (NIH)	R01 CA266579
American Cancer Society-Michigan Cancer Research Fund	IRG 19–140-31

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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10.1186/s10020-023-00706-6

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Akinyemi, A. O., Simpson, K. E., Oyelere, S. F., Nur, M., Ngule, C. M., Owoyemi, B. C. D., Ayarick, V. A., Oyelami, F. F., Obaleye, O., Esoe, D. P., Liu, X., & Li, Z. (2023). Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review. Molecular Medicine, 29(1), Artículo 112. https://doi.org/10.1186/s10020-023-00706-6

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title = "Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review",

abstract = "Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to the cell surface (csGRP78) were it interacts with different ligands to initiate various intracellular pathways. The expression of csGRP78 has been associated with tumor initiation and progression of multiple cancer types. This review provides a comprehensive analysis of the existing evidence on the roles of GRP78 in various types of cancer and other human pathology. Additionally, the review discusses the current understanding of the mechanisms underlying GRP78's involvement in tumorigenesis and cancer advancement. Furthermore, we highlight recent innovative approaches employed in downregulating GRP78 expression in cancers as a potential therapeutic target.",

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AU - Nur, Maria

AU - Ngule, Chrispus Mutuku

AU - Owoyemi, Bolaji Charles Dayo

AU - Ayarick, Vivian Adiila

AU - Oyelami, Felix Femi

AU - Obaleye, Oluwafunminiyi

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AU - Liu, Xiaoqi

AU - Li, Zhiguo

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AB - Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to the cell surface (csGRP78) were it interacts with different ligands to initiate various intracellular pathways. The expression of csGRP78 has been associated with tumor initiation and progression of multiple cancer types. This review provides a comprehensive analysis of the existing evidence on the roles of GRP78 in various types of cancer and other human pathology. Additionally, the review discusses the current understanding of the mechanisms underlying GRP78's involvement in tumorigenesis and cancer advancement. Furthermore, we highlight recent innovative approaches employed in downregulating GRP78 expression in cancers as a potential therapeutic target.

KW - BiP

KW - Cancer

KW - Chaperon

KW - Disease

KW - ER stress

KW - ERAD

KW - GRP78

KW - URP

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DO - 10.1186/s10020-023-00706-6

M3 - Review article

C2 - 37605113

AN - SCOPUS:85168459940

SN - 1076-1551

VL - 29

JO - Molecular Medicine

JF - Molecular Medicine

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Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

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