Resumen
The first Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop, held on May12-16, 2025 at The Jackson Laboratory, provided scientific content and career development training in the latest developments in VCID and Alzheimer’s Disease (AD) and related dementia (ADRD). The Workshop aimed to foster interdisciplinary collaborations and empower the next generation of diverse scientists to advance ADRD research from mechanism to intervention. The meeting placed a strong emphasis on neurovascular pathology, its central role in ADRD pathogenesis, its modulation by both central and peripheral factors, and the critical need to dissect the mechanistic basis of VCID through experimental models. The workshop included talks from both faculty and trainees and was bookended by two keynote addresses by Drs. Donna Wilcock and Costantino Iadecola, leaders and pioneers in the VCID field. The second VCID workshop is planned for April 28-May 1, 2026, to be held at Washington University in St. Louis.
| Idioma original | English |
|---|---|
| Número de artículo | 44 |
| Publicación | Mammalian Genome |
| Volumen | 37 |
| N.º | 1 |
| DOI | |
| Estado | Published - dic 2026 |
Nota bibliográfica
Publisher Copyright:© The Author(s) 2026.
Financiación
Held in a residential setting at the Highseas Conference Center at The Jackson Laboratory, the workshop brought together experts in vascular biology, neurodegeneration, ADRD, and computational research to advance understanding of key mechanisms underlying VCID, including small vessel disease, cerebral amyloid angiopathy, and blood–brain barrier dysfunction. The program convened 26 in-person participants spanning multiple career stages (2 faculty, 9 postdoctoral fellows, 11 graduate students, and 4 participants in other roles), with strong gender representation (58% female, based on voluntary self-identification). To promote accessibility and broad participation, 24 attendees (92%) received full or partial scholarships supported by a NIH grant (R13NS141586) and the Diana Davis Foundation. The scientific program featured 12 invited speakers from across the United States as well as Canada and England, providing a rich perspective. Trainees gained hands-on experience in grant conceptualization through structured, study section-style sessions, working directly with accomplished investigators, strengthening both scientific rigor and proposal development skills. The immersive format fostered meaningful faculty–trainee interactions, organic networking, and the formation of new cross-disciplinary collaborations. Post-course evaluations demonstrated strong impact and satisfaction, with the workshop earning a Net Promoter Score of + 50, 100% of respondents agreeing or strongly agreeing that their objectives for attending were met, and over 75% reporting high satisfaction that “the event provided an appropriate balance of scientific overview and specific information” and “overall I was satisfied with the quality of instruction”. Participant feedback also provided constructive guidance, identifying opportunities to further enhance future iterations of the workshop by optimizing the grant-writing training component. Overall, the workshop successfully trained a diverse cohort of emerging investigators, catalysed new collaborative partnerships, and empowered future leaders poised to advance therapeutic discovery across the VCID and ADRD spectrum. Based on the success of the first VCID workshop, The Jackson Laboratory will host the second workshop, to be held on April 28-May 1, 2026 at Washington University in St Louis (Vascular Contributions to Cognitive Impairment and Dementia workshop). Hosted by The Jackson Laboratory in Bar Harbor, Maine with funding from the Diana Davis Spencer Foundation and the National Institute of Neurological Disorders and Stroke, the 2025 Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop convened experts from multiple disciplines to discuss challenges in VCID pathophysiology and treatment. The workshop brought together scientists across the career spectrum, including graduate students, postdoctoral fellows, and junior and senior faculty, from the fields of vascular biology, neurodegeneration, genetics of ADRD, and computational biology. The meeting had a particular focus on neurovascular pathology, including the crucial role it plays in AD and ADRD pathogenesis and how it can be affected by central and peripheral influences. A critical need for understanding the mechanistic underpinnings of VCID for development of robust biomarkers and interventions was identified. Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop 2025 at the Jackson Laboratory was funded by Diana Davis Spencer Foundation and National Institute of Neurological Disorders and Stroke (R13NS141586).
| Financiadores | Número del financiador |
|---|---|
| Diana Davis Foundation | |
| Jackson Laboratory | |
| Spencer Foundation | |
| NIH | R13NS141586 |
| Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council | R13NS141586 |
ASJC Scopus subject areas
- Genetics
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