When Alzheimer's is LATE: Why Does it Matter?

Peter T. Nelson; Julie A. Schneider; Gregory A. Jicha; Michael Tran Duong; David A. Wolk

doi:10.1002/ana.26711

When Alzheimer's is LATE: Why Does it Matter?

Peter T. Nelson
, Julie A. Schneider
, Gregory A. Jicha
, Michael Tran Duong
, David A. Wolk

Producción científica: Review article › revisión exhaustiva

50 Citas (Scopus)

Resumen

Recent therapeutic advances provide heightened motivation for accurate diagnosis of the underlying biologic causes of dementia. This review focuses on the importance of clinical recognition of limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE affects approximately one-quarter of older adults and produces an amnestic syndrome that is commonly mistaken for Alzheimer's disease (AD). Although AD and LATE often co-occur in the same patients, these diseases differ in the protein aggregates driving neuropathology (Aβ amyloid/tau vs TDP-43). This review discusses signs and symptoms, relevant diagnostic testing, and potential treatment implications for LATE that may be helpful for physicians, patients, and families. ANN NEUROL 2023;94:211–222.

Idioma original	English
Páginas (desde-hasta)	211-222
Número de páginas	12
Publicación	Annals of Neurology
Volumen	94
N.º	2
DOI	https://doi.org/10.1002/ana.26711
Estado	Published - ago 2023

Nota bibliográfica

Publisher Copyright:
© 2023 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

Financiación

The authors sincerely thank patients and colleagues who enabled this work. Funding was from NIH/NIA grants R01 AG061111 (G.A.J. and P.T.N.), P30 AG072946 (G.A.J. and P.T.N.), RF1 NS118584 (P.T.N.), F30 AG074524 (M.T.D.), P30 AG072975 (J.A.S.), R01 AG067482 (J.A.S.), UF1 NS100599 (K.A. and J.A.S.), R01 AG064233 (K.A. and J.A.S.), P30 AG072979 (D.A.W.), RF1 AG069474 (D.A.W.), and R01 AG072796 (D.A.W.). Thanks to Dr. Karin Nelson for editorial review and suggestions.

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Institute on Aging	P30 AG072975, R01 AG064233, UF1 NS100599, RF1 NS118584, R01 AG067482, RF1 AG069474, F30 AG074524, P30 AG072946, P30 AG072979, R01 AG061111, R01 AG072796
National Institute on Aging

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "When Alzheimer's is LATE: Why Does it Matter?",

abstract = "Recent therapeutic advances provide heightened motivation for accurate diagnosis of the underlying biologic causes of dementia. This review focuses on the importance of clinical recognition of limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE affects approximately one-quarter of older adults and produces an amnestic syndrome that is commonly mistaken for Alzheimer's disease (AD). Although AD and LATE often co-occur in the same patients, these diseases differ in the protein aggregates driving neuropathology (Aβ amyloid/tau vs TDP-43). This review discusses signs and symptoms, relevant diagnostic testing, and potential treatment implications for LATE that may be helpful for physicians, patients, and families. ANN NEUROL 2023;94:211–222.",

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note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",

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AU - Wolk, David A.

PY - 2023/8

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JF - Annals of Neurology

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When Alzheimer's is LATE: Why Does it Matter?

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