ZWEITMALIGNOME NACH ERFOLGREICH THERAPIERTEM MORBUS HODGKIN

Due to advances in chemo- and radiation therapy Hodgkin's disease has become a potentially curable disease. Secondary malignancies after successful treatment of Hodgkin's disease are an important late event. The question has to be asked how many of the second tumors are treatment-related, or if these patients show a genetic predisposition to develop malignant tumors. The study presented here is part of an investigation supported by the W. Vaillant foundation. Patients with secondary malignancies are analysed and risk factors will be defined. We present 142 patients with Hodgkin's disease treated between June 1961 and June 1993. 14 of 142 patients developed a secondary malignancy during a mean follow-up time of 9.6 years. 10 years after diagnosis of Hodgkin's disease there was a cumulative frequency of 6%, and after 20 years of 20%. Solid tumors of different histologic origin and leukemias were observed.